NeXST(Next Xight Screening Test)
-(Cardiac Safety Service)

NEXEL’s NeXST Cardiac Safety Service aims to aid our collaborators make efficient decisions for their drug development programs. Although current safety guidelines have successfully eliminated hERG-related risk issues there are many concerns over the accuracy of the assay as hERG-block does not always equate to QT prolongation in patients. Many other ion channels are involved, as well as calcium handling or contraction-related, not covered at all by the hERG assay. NEXEL is a member of the HESI CiPA working group and is currently participating in the ICH guideline revision making novel assays including iPS-Cardiomyocytes mandatory to preclinical toxicity testing. Our integrated Cardiac Safety platform has been extensively validated to provide accurate results based on the most recent standards.

NEXEL provides its Cardiac Safety Service using its own Cardiosight®-S, making costs and experimental designs much more flexible. Reach out to us now and make your drug cardio-safe!

Electrophysiology, Contractility, Viability - All-in-one Service

Cardiac Safety Service | Cardiotoxicity Test Screening